The activation of RhoA, a small GTPase involved in reorganizing actin cytoskeleton and a mediator of EGF induced invasion of pancreatic cancer cell lines is inhibited in MCF-7 cells by the relocation of Gα13 to the plasma membrane by RGS16 preventing Gα13 mediated activation of RhoA [18, 71]. Here, RHOA is linked to familial pancreatic carcinoma.