To investigate if exogenous and endogenous p53 and pRb interactions could influence expression profiles expression of RGS16, BCL2L11, BTG-2, IL-6, and STAT4, were measured using qRT-PCR in the p53 null and pRb mutated osteosarcoma cell line SAOS-2. The gene discussed is BTG2; the disease is osteosarcoma.