As shown in figure 5C, XTT proliferation assays demonstrated that U87 GBM cells stably overexpressing DUSP10 224A/230A were significantly more resistant to PP242 as compared to cells overexpressing wild-type DUSP10, however we also observed that native DUSP10 significantly decreased resistance to the drug upon overexpression. The gene discussed is DUSP10; the disease is glioblastoma.