We chose the AAFP of two good-risk AMLs — the t(8;21)-related RUNX1/RUNX1T1 and the t(15;17)-related PML/RARα — and of one poor risk AML — the t(6;9)-related DEK/NUP214 (Figure 1A). The gene discussed is RARA; the disease is acute myeloid leukemia.