Taken together, these data show that the leukemic phenotype induced by PML/RARα or DEK/NUP214 is associated with a constitutive activation of STAT3 and/or 5 and that the targeted expression of the AAFPs to different subpopulations in the BM might have different intracellular signaling responses that contribute to leukemia development. The gene discussed is NUP214; the disease is leukemia.