Thus, initiating antihypertensive treatment with an angiotensin-converting-enzyme (ACE) inhibitor resulted in a reduction in ECG-evaluated left ventricular hypertrophy, which was associated with a concomitant reduction in both cardiovascular death and events (17), and ECG-evaluated left ventricular hypertrophy reductions in patients with resistant hypertension have been associated with a lower risk of cardiovascular events (18). The gene discussed is ACE; the disease is left ventricular hypertrophy.