Decreases in NEP mRNA, protein level, and activity are observed in the postmortem AD hippocampus (Yasojima et al., 2001; Caccamo et al., 2005; Wang et al., 2005), and NEP protein expression is inversely correlated with the severity of Aβ accumulation and cognitive impairment (Wang et al., 2010). The gene discussed is MME; the disease is Cognitive impairment.