Hereditary sensory and autonomic neuropathy type I (HSAN1) is an autosomal dominant ulceromutilating neuropathy with variable motor involvement caused by mutations in six genes: SPTLC1 (Bejaoui et al. 2001; Dawkins et al. 2001), SPTLC2 (Rotthier et al. 2010), ATL1 (Guelly et al. 2011), RAB7 (Verhoeven et al. 2003), DNMT1 (Klein et al. 2011) and ATL3 (Kornak et al. 2014). This evidence concerns the gene SPTLC1 and hereditary sensory and autonomic neuropathy type 1.