PGE2 has been implicated in regulating fetal pulmonary surfactant production both in vitro (Acarregui et al., 1990) and in vivo in a sheep model of intra-amniotic infection (Westover et al., 2012); suggesting that the 15-epi-lipoxin A4-induced increase in utero-placental Ptgs2 expression may promote fetal lung maturation via increased local PGE2 production. The gene discussed is PTGS2; the disease is chorioamnionitis.