With respect to SPT responses and serum specific IgE levels to peanut possibly reflecting the severity of allergic reactions to peanut, previous studies showed contradictory results, with some showing that SPT responses and serum specific IgE levels predicted the development of anaphylaxis6,31-33 and others not finding any association between allergy test results and the severity of allergic reactions.4,25 In our study, patients with severe reactions had higher levels of specific IgE to peanut, Ara h 1, and Ara h 2. The gene discussed is IGHE; the disease is allergic disease.