IGHE and allergic disease: The response of basophils of allergic patients to allergen has been reported to be greater than that to anti-IgE or anti-FcεRI.27,28 In a previous study of children with cow's milk allergy,28 the ratio between the percentage of CD63 basophils in response to cow's milk and to anti-FcεRI was higher in patients with persistent cow's milk allergy compared with that in patients who outgrew their allergy and was correlated with the severity of the reactions during challenges.