APP has been shown to be rapidly translated in the synapses in response to DHPG, agonist of group I mGluRs60, and such activation stimulates the release of Aβ1–42 in cortical synaptoneurosomes in a mouse model of AD, while stimulation of group II mGluRs triggers production and release of both Aβ1–42 and Aβ1–4061. This evidence concerns the gene APP and Alzheimer disease.