Curcumin successfully down related Caveolin-1 (Cav-1, an important structural component in tumor metastasis which can potentiate the invasive ability by up-regulating CD-147 glycosylation level), and inhibited the phosphorylation of EGFR and the corresponding downstream targets such as MMP-2 and -9 as well as the phosphoinositilde 3-kinase (PI3K)/protein kinase B (Akt), p38 mitogen-activated protein kinase (MAPK), and p44/42MAPK (Wang et al., 2011). Here, AKT1 is linked to neoplasm.