The inhibition of cell proliferation might be because of repression of NF-κB p65 and consequently COX-2 whereas the down regulation of PKC, FAK, and Rho A as well as their downstream targets ERK1/2, MKK7, and ROCK1 led to the overall down regulation of MMP-2 and -9, responsible for N18 cancer cells migration and invasion (Lin et al., 2010). The gene discussed is MMP2; the disease is cancer.