Curcumin inhibited the androgen independent human prostate cancer DU145 and PC3 cell proliferation in a dose-dependent manner and showed its activity to decrease extensively the cell migration as well as the detachment of cells seeded on laminin or fibronectin by selectively activating the ERβ, the only isoform present in these prostate cancers. This evidence concerns the gene ESR2 and Familial prostate cancer.