EGFR has been shown to inhibit expression of the Notch-1 gene in a squamous-cell carcinoma model by up-regulating c-Jun, which in turn down-regulates p53, causing repression of Notch-1 transcription, and this form of Notch-1-EGFR crosstalk occurs via the MAPK/MEK/ERK pathway (84). The gene discussed is EGFR; the disease is squamous cell carcinoma.