EGFR and non-small cell lung carcinoma: Current investigation of the bidirectional communication between EGFR and Notch led to its observation in non-small cell lung cancer by Xie et al. as a route of acquired resistance to EGFR targeted TKIs and development of the EMT phenotype via Notch-1 mediated down-regulation of E-cadherin (epithelial marker), as well as up-regulation of vimentin (mesenchymal marker), and Snail (mesenchymal marker) expression (86).