Decreased A subunit expression is observed in myeloid cells expressing activated c-KIT mutants (113), while loss of Aβ function occurs with low frequency in ALL (G90D mutation, 3/150) (114), B-CLL (exon skipping and reduced mRNA expression) (115, 116), and AML (117). The gene discussed is KIT; the disease is B-cell chronic lymphocytic leukemia.