Several mechanisms of PP2A dysfunction in hematologic malignancies have been reported, including changes in expression of PP2A subunits and inhibitors (by epigenetic or other mechanisms), genomic alterations in PP2A subunit and regulator encoding genes (including mutations, deletions, splicing errors, chromosomal translocations), and alterations in subunit modifications affecting PP2A activity. Here, PTPA is linked to hematologic disorder.