Acute urticaria, diarrhea, kidney failure, elevated IgE due to other allergy or urticaria reasons, epilepsy, antibiotic allergic reactions, malignancies in the last 5 years, CVA or ischemia, IV steroid use, methotrexate, cyclosporine or other immunosuppressant 4 weeks before. This evidence concerns the gene IGHE and epilepsy.