TP53 and cancer: Due to the nature of the distinct p53 binding patterns (enrichment at hypomethylated DNA and CGIs in the normal cell line; depletion from CGIs and higher enrichment at repeats in the cancer cell lines), it was proposed that epigenetic changes accompanying cancer progression (local CGIs hypermethylation and global genomic hypomethylation) modulate p53 binding to the genome (Botcheva et al., 2011).