The distinct p53 binding patterns in HCT116 and IMR90 likely reflect differences in the epigenetic landscapes in these cell lines, due to cancer-associated changes (accumulated in HCT116), overlaid on tissue-specific differences (HCT116 has epithelial, while IMR90 has mesenchymal origin; Botcheva and McCorkle, 2014). Here, TP53 is linked to cancer.