CD4 and systemic lupus erythematosus: Although the effect of CD70 upregulation in pSS CD4+ T cells has yet to be investigated, Zhou et al. (2011) analyzed the histone modifications in the TNFSF7 promoter region of SLE patients and linked it to a global histone H3 and H4 hyperacetylation and increased dimethylation of H3 lysine 4 (H3K4me2).