Other studies look at DNA methylation in fibroblasts that contribute to the excessive deposition of collagen and extracellular matrix and how DNMT inhibitors such as 5-aza-2′-deoxycytidine (2-deoxy-5-azaC; 5-Aza-CdR; decitabine) can reverse this pathology in SSc fibroblasts (Wang et al., 2006). Here, DNMT1 is linked to systemic sclerosis.