CD4 and systemic lupus erythematosus: One study found that the overexpression of miR-125 correlates to the reduction of DNMT1 protein expression in lupus CD4+ T cells (Zhao et al., 2011), and another study reported overexpression of miR-126 in healthy donor CD4+ T cells that led to hypomethylation and overexpression of genes CD11a and CD70 (Pan et al., 2010).