Immunoglobulins (Igs) may claim to be, historically, the first therapeutic plasma product, with Emil von Behring’s work on diphtheria antitoxin and von Behring and Kitasato’s demonstration (1) that serum of rabbits immunized with tetanus toxin contained activity against experimentally induced tetanus poison, which provided protection to non-immunized rabbits exposed to tetanus. This evidence concerns the gene CUBN and tetanus.