Cytokines synthesized by platelets or in response to platelet-dependent signaling of monocytes, including IL-1β, IL-8, tumor necrosis factor (TNF)-α, and monocyte chemotactic protein (MCP)-1 (19), are increased in plasma from dengue patients and correlate with the degree of thrombocytopenia (46). The gene discussed is TNF; the disease is dengue disease.