Indeed, B-ALL cell lines coated with mAb were lysed by CD16+ Vγ9Vδ2 cells via ADCC, and subsequently the Vγ9Vδ2 had antigen presenting cell function to generate antigen-specific CD8+ αβ T cell responses to known B-ALL peptides, e.g., PAX5 (114, 115). This evidence concerns the gene PAX5 and precursor B-cell acute lymphoblastic leukemia.