In Paracoccidioides spp., MLS participates in the glyoxylate cycle and allantoin degradation, which allows the cell to use purine as a nitrogen source (Zambuzzi-Carvalho et al., 2009); MLS is likely important for infection because its transcript is up-regulated during the mycelium to yeast transition, during the infectious phase (Bastos et al., 2007), and, in yeast cells, during phagocytosis by murine macrophages (Derengowski et al., 2008). Here, HCCS is linked to infection.