PRKG1 and Naxos disease: An in vitro model for Naxos disease using neonatal rat cardiomyocytes transfected with an adenovirus encoding the PKG 2057del2 mutation recapitulated all abnormalities seen in patients: reduced plakoglobin and Cx43 signal at the ICD's, increased apoptosis and secretion of inflammatory mediators (Asimaki et al., 2014).