KRAS and pancreatic ductal adenocarcinoma: Among the GTPases, constitutive Ras activation plays a critical role in the development of pancreatic, colon, and lung cancers, and is an indicator of poor prognosis (Kim et al., 2006; Califano et al., 2012; Pérez-Ruiz et al., 2012), with the Kristin isoform of Ras (K-Ras) being mutated in over 90% of pancreatic ductal adenocarcinomas (PDAC) (Morris et al., 2010).