RYR1 and centronuclear myopathy: RYR1 mutations are one of the most common causes of inherited neuromuscular disorders, ranging from the malignant hyperthermia susceptibility (MHS) trait without any associated weakness to various congenital myopathies, including mainly dominantly inherited Central Core Disease (CCD) as well as mainly recessively inherited Multi-minicore Disease (MmD) [for review, see Jungbluth et al. (2011)], CFTD (Clarke et al., 2010), and CNM (Wilmshurst et al., 2010).