TTN mutations have recently also been indicated as one of the most common identifiable genetic causes of dilated cardiomyopathy (Herman et al., 2012), and have been implicated in a wide range of neuromuscular disorders, including late-onset tibial muscular dystrophy, limb girdle muscular dystrophy type 2J (LGMD2J), hereditary myopathy with early respiratory failure (HMERF), and early-onset myopathy with fatal cardiomyopathy [reviewed recently in Chauveau et al. (2014b)]. This evidence concerns the gene TTN and autosomal recessive limb-girdle muscular dystrophy type 2J.