As the amygdala is known to mediate memories with emotional content (Herry et al., 2010; Lüthi and Lüscher, 2014) and to project extensively to the AcbShm (Heimer et al., 1997), it is plausible that amygdala-AcbShm projections modulate the effect of anxiety on AcbShm MSN activation. This evidence concerns the gene MSN and Anxiety.