EGR1 and Anxiety: With respect to baseline EGR1- and c-Fos activation of accumbens corridor D1- and D2-MSNs in high anxiety- vs. normal anxiety mice, which may have given us an indication if anxiety per se results in an increased activation of accumbens corridor MSNs, our findings are equivocal: HAB mice showed an increased baseline EGR1 expression in the ICjM + LSI (Figure 6A and Table 1), whereas baseline c-Fos activation was increased in a different region, i.e., the AcbCm (Figure 6B and Table 1), allowing no firm conclusion.