In this Research Topic, Cash-Padgett and Jaaro-Peled outline how either early immune activation (i.e., PolyI:C treatment) or forms of social stress (i.e., social isolation, chronic social defeat) influence the development of schizophrenia-relevant phenotypes in a number of genetic mouse models for the schizophrenia susceptibility gene Disrupted in schizophrenia-1 (DISC1). Here, DISC1 is linked to schizophrenia.