As a final remark about drug dosage, LP-211 (10 mg/kg) has been used in various in vivo studies (Hedlund et al., 2010; Martinez-Garcia et al., 2014; Meneses et al., 2014), and effects possibly mediated by the activation of 5-HT1A or 5-HT2B receptors were not observed (i.e., body temperature, cardiac failure, respectively). Here, HTR1A is linked to heart failure.