Along with the formation of alpha-synuclein-rich intraneuronal protein aggregates termed Lewy Bodies in various brain regions (Spillantini et al., 1997; Braak et al., 2003; Burke et al., 2008), the progressive loss of pigmented SNpc DA neurons is a pathological hallmark of PD (Brichta et al., 2013). The gene discussed is SNCA; the disease is Parkinson disease.