On gene transcription, the CAG-containing ATXN8 and CUG-containing ATXN8 opposite strand (ATXN8OS) transcripts were detected in SCA8 patients (Moseley et al., 2006), and nuclear CUG ATXN8OS foci were found in HEK293 cells (Chen et al., 2009), the SCA8 mouse model and SCA8 patients (Daughters et al., 2009). This evidence concerns the gene ATXN8 and spinocerebellar ataxia type 8.