Thus, we exposed mice to intraluminal middle cerebral artery occlusion (MCAO) and investigated effects of the HMG-CoA reductase inhibitor rosuvastatin, administered starting 3 days post-ischemia (dpi), on functional neurological recovery, peri-lesional brain remodeling, and contralesional pyramidal tract plasticity. Here, HMGCR is linked to ischemia.