HMGCR and stroke disorder: It has previously been shown that HMG-CoA reductase inhibition promotes post-ischemic neuronal survival in the acute stroke phase (Sironi et al., 2003; Kilic et al., 2005), inhibit brain inflammation (Pahan et al., 1997; Kilic et al., 2005), restore endothelial function (Endres et al., 1998; Amin-Hanjani et al., 2001), and promote angiogenesis and neurogenesis (Chen et al., 2003).