However, it seems that HPA axis and sympathetic nervous system activity (Gold and Chrousos, 2002), as well as that of circulating IL-1β and IL-6 (Anisman et al., 1999; Dunjic-Kostic et al., 2013), may vary greatly in individuals with typical vs. atypical features of major depression. The gene discussed is IL1B; the disease is major depressive disorder.