Expression changes of chemoprotective transporters, such as P-glycoprotein and Breast Cancer Resistance Protein, have already been shown to occur in disease states including Alzheimer's disease and epilepsy (Vogelgesang et al., 2002; Loscher and Potschka, 2005; Miller, 2010). This evidence concerns the gene ABCB1 and early-onset autosomal dominant Alzheimer disease.