At the protein level, RUNX1 expression in cylindroma has recently been highlighted by Scheike et al. [20], and our data extends the expression of RUNX1 to include spiradenoma and trichoepithelioma, suggesting that this is a feature consistent across CYLD defective tumours. The gene discussed is RUNX1; the disease is adnexal spiradenoma/cylindroma of a sweat gland.