CD4 and colitis: Several studies also demonstrated that daikenchuto has an anti-inflammatory effect in experimental models of colitis including trinitrobenzenesulfonic acid-induced, helper type-1 T cell (Th1)- [20] and oxazolone-induced helper type-2 T cell (Th2)-dominant colitis [21], naive CD4+ T cell transfer [27], and intestinal mucositis induced by chemotherapeutic agent irinotecan [22].