ZEB2 and acute lymphoblastic leukemia: However, ZEB2 overexpression experiments in JURKAT, a mature T-ALL cell line that lacks the characteristic immature/ETP-ALL mRNA expression profile, did not yield any correlated expression with IL7R (Supplementary Fig. 10c), suggesting that an ETP-ALL-specific co-factor might be essential for the ZEB2-mediated effects on IL7R gene expression.