TLX3 and acute lymphoblastic leukemia: Interestingly, the BCL11B gene resides in chromosome band 14q32 and given its implication in translocations leading to overexpression of several bona fide T-ALL oncogenes, such as HOX11L2/TLX3, HOXA13 (refs 12, 13) and NKX2-5 (refs 14, 15), we performed fluorescence in situ hybridization (FISH) analysis using locus-specific probes.