Using the T-cell-restricted CD4-Cre line to overexpress Zeb2 recapitulated the spontaneous thymoma formation and strongly suggests a cell autonomous role of Zeb2, however, given the paracrine effects associated with Zeb2 deletion in the central nervous system34, we cannot exclude environmental involvement in the observed T-cell lymphoma formation phenotype. This evidence concerns the gene ZEB2 and thymoma.