Based on our microarray expression analysis and focusing on genes previously identified as recurrently mutated in immature/ETP-ALL7, we found a significant and Zeb2 dosage-dependent increase in Il7r mRNA (Fig. 3a), which was confirmed by qRT–PCR analysis (a 8.5-fold increase in the P53/R26-Zeb2tg/+ and a 17-fold increase P53/R26-Zeb2tg/tg tumours compared with p53/R26+/+ control tumours; Fig. 5a). This evidence concerns the gene ZEB2 and neoplasm.