RYR1 and myopathy: We propose that the waves of increased calcium into the mitochondria enhance ATP production (Griffiths and Rutter, 2009), which inhibits KATP channel opening and reverses the K+ leak, and stimulates RyR1-dependent calcium release from internal stores (Meissner et al., 1986; Laver et al., 2001), further perpetuating mitochondrial ATP production in this model of myopathy in which the phenotype can be ameliorated by increased potassium.