TRPM8 and memory impairment: The idea that DPMs can act acutely is in agreement with the literature that shows there is a temporally circumscribed window during which they are required for consolidation (Keene et al., 2004, 2006; Yu et al., 2005) and with the finding that a short period (45 min) of TrpM8 activation of DPM neurons following a learning task rescues age-induced memory impairment (Tonoki and Davis, 2012).