CENPF and autosomal recessive primary microcephaly: We identified two CENPF mutated alleles [c.1744G>T, p.E582*, c.8692 C>T, p.R2898*] in a patient with MCPH associated with mild to moderate learning difficulties (occipital head circumference (OFC) at birth: 29.5 cm, below 0.4th centile; adult OFC 45.5 cm, below 0.4th centile, figures 1C, D and 2A, B; see online supplementary figure S4).