The enriched KEGG pathway categories unique for this comparison were the Wnt signaling pathway, TGF-β signaling pathway, cadherin signaling pathway, melanogenesis, and Alzheimer's disease-presenilin pathway, where some named categories shared common genes from the five: Bace2, Wnt16, Wnt6, Cdh1, and Cdh3, members of the set of notably variable in average expression genes (Additional file 2, 3). This evidence concerns the gene CDH3 and early-onset autosomal dominant Alzheimer disease.