ELOVL1 and ichthyosis: The product of Elovl1 gene ortholog, ELOVL fatty acid elongase 1, participates in the metabolism of very long-chain fatty acids (VLCFAs) and a variety of inherited diseases, such as ichthyosis, macular degeneration, myopathy, mental retardation, and demyelination, which are caused by mutations in the genes encoding VLCFA-metabolizing enzymes [110,111].