Topalian et al. [46] conducted a phase I study examining the safety and efficacy of a fully humanized mAb, directed at PD-1 blockade and showing a cumulative objective response rate of 18% in NSCLC patients, while the second study utilized PD-L1-specific mAb [47] that inhibits PD-1–PD-L1 binding, with 10% objective response in NSCLC. Here, CD274 is linked to non-small cell lung carcinoma.