In a Phase I first in class trial of the orally available ALK TKI crizotinib (Xalkori, Pfizer) an Objective Response Rate of 61% with an estimated median Progression free survival of 10 months was reported in a cohort of 116 patients with ALK-positive NSCLC identified by Fluorescence in situ hybridization (FISH) using break-apart probes [22,23]. This evidence concerns the gene ALK and non-small cell lung carcinoma.