Other examples in this class include epidermal growth factor receptor (EGFR), insulin-like growth factor receptor 1 (IGF-1R), hepatocyte growth factor receptor (HGFR), platelet-derived growth factor receptor (PDGFR), etc. Cell surface targets in the second class are not necessarily directly expressed by the tumor cell but rather by the host environment feeding the tumor and are required for tumor maintenance and metastasis. This evidence concerns the gene IGF1R and neoplasm.