UBQLN2 and amyotrophic lateral sclerosis: In addition to the SOD1 gene, several other genes have also been implicated in ALS pathogenesis, including the TAR DNA binding protein (TARDBP), fused in sarcoma (FUS), angiogenin (ANG), ubiquilin 2 (UBQLN2), and valosin-containing protein (VCP) genes [181,182,183,184,185,186,187,188,189].