Given the price of Xalkori (£78,000 per year), the current price of ALK testing (£900) for the ALK testing, and considering the rather low prevalence of ALK translocations, testing all advanced NSCLC patients in order to identify ALK-positive patients might turn out not to be cost effective [41], an issue noted by others [10]. The gene discussed is ALK; the disease is non-small cell lung carcinoma.