Todays, the most available clinical research in treating AD pathology try to augment of the neurotransmitter acetylcholine (14,15) so these drugs (tacrine, donepezil, rivastigmine and galantamine) have included acetylcholine precursors, muscarinic agonists, nicotinic agonists, and acetylcholinesterase inhibitors (16). This evidence concerns the gene ACHE and Alzheimer disease.