NF-L (Figure 2d) binds to Mapk12 (mitogen-activated protein kinase 12), Mapk13, Mapk14, Nefh (neurofilament), Nefm, Prph (peripherin) and Prph2 which are involved in pathway associated to Amyotrophic Lateral Sclerosis (ALS). This evidence concerns the gene PRPH2 and amyotrophic lateral sclerosis.