For example, the vasculo-protective effects of statins may have important implications for preventing TOD in hypertension by maintaining vascular eNOS activity, reducing endothelin-1 expression, down-regulating Ang II AT1 receptor expression, and by inhibiting NADPH oxidase activity, with the consequent inhibition of oxidative stress accumulation [87,88,89,90]. This evidence concerns the gene FMO5 and hypertensive disorder.