PPARGC1A and Hypertension: Molecular signaling pathways linking ROS to cardiac hypertrophy and remodeling in hypertension include calcium channels (ICa), α and β adrenergic receptors, Ang II AT1 receptor, collagen and MMPs, modification of stress kinases (mitogen-activated protein kinases-MAPK), phosphoinositol 3-kinase (PI3K), apoptosis signaling kinase-1 (Ask-1), PKC, sarcomeric and excitation–contraction coupling proteins, nuclear transcription factors such as nuclear factor κB, activator protein-1, peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) [41,42].