Mutation of p53 (R248Q) was identified in one responder with ADC, and in 5 non-responders (G245C, R273L, R249S, Y220C, R158C), 2 of these in a squamous cell carcinoma (SCC), 2 in ADC and one in large cell carcinoma. This evidence concerns the gene TP53 and large cell carcinoma.