In the whole population, a significant association was found between the ADIPOQ gene +45T>G polymorphism and the T2DM under allelic (OR: 1.18, 95% CI: 1.06–1.32, p = 0.002), dominant (OR: 1.18, 95% CI: 1.03–1.34, p = 0.014), recessive (OR: 1.47, 95% CI: 1.20–1.80, p < 0.001), homozygous (OR: 1.62, 95% CI: 1.25–2.09, p < 0.001), and heterozygous (OR: 1.11, 95% CI: 0.98–1.24, p = 0.11). Here, ADIPOQ is linked to type 2 diabetes mellitus.