APC and malignant colon neoplasm: Many markers such as adenomatous polyposis coli (APC), DNA mismatch repair genes, vascular endothelial growth factors (VEGFs) and their receptors, and, more recently, microRNAs and colon epithelial stem cell markers, have been systematically analyzed for diagnosis and prognosis of colon cancer [7,8,9,10,11,12].