TAOK2 and major depressive disorder: The locus 16p11.2 has been also previously implicated in neuropsychiatric disorders via a genome-wide association study of mixed SZ and BD (psychosis) phenotypes, which revealed a novel variant at 16p11.2 showing genome-wide association for rs4583255 (P-value 6.6 × 10−11, odds ratio=1.08) located in the 593-kb CNV duplication region33 within the gene TAOK2. A significant excess of a combination of microdeletions and duplications at 16p11.2 has also been reported in major depressive disorder in a German sample.34