The expression of HES5 is low or undetectable in cultured prostate cancer cell lines and is also low in human prostate tumours (Supplementary Figure 5a, c, see section on supplementary data given at the end of this article and Fig. 3d, f), consistent with epigenetic silencing of HES5 in prostate cancer (Supplementary Figure 5g and h). The gene discussed is HES5; the disease is Familial prostate cancer.