Combining our observations of HES5 silencing in prostate cancer with expression correlations in prostate tissue, DNA binding profiles for ERG and the AR and published transcriptional links (i.e. between HES5 and HES6 (Fior & Henrique 2005), HES1 and HES6 (Jacobsen et al. 2008), reciprocal HES6 and HES1/5 negative-feedback (Bae et al. 2000, Salama-Cohen et al. 2005, Hatakeyama et al. 2006) and AR and HES6 (Ramos-Montoya et al. 2014)), we constructed models of putative gene expression networks in benign prostate, prostate cancer and prostate cancer harboring ERG-rearrangements (Fig. 3j). Here, HES1 is linked to Familial prostate cancer.