Despite the early and frequent silencing of HES5 in prostate cancer, we observed variable expression of the HES5 transcriptional target HES6 in prostate tumour samples (Fior & Henrique 2005) (Fig. 3f and Supplementary Figure 5f), prompting us to investigate other factors that may regulate HES6 expression in prostate tumour cells. The gene discussed is HES5; the disease is prostate neoplasm.