At the first postoperative day, the median [TIMP-2] × [IGFBP-7] concentration of patients without AKI was 0.28 (ng/ml)2/1,000, whereas patients with AKI had a significantly higher [TIMP-2] × [IGFBP-7] concentration of 0.79 (ng/ml)2/1,000 (Figure 1 and Table 4). Here, IGFBP7 is linked to acute kidney injury.